Hampden South is a residential neighborhood approximately 10 miles southeast of downtown Denver. The area lies to the south of East Hampden Avenue and expands between Interstate 25 and Yosemite Street until it reaches Bellevue Avenue. Other major motorways include Interstate 225, Tamarac Drive, Quincy Avenue and Union Avenue. From Hampden South, downtown Denver averages a 30-minute commute by car. Public light rail transportation is also available. 

Hampden South boasts a wide range of local amenities including a Whole Foods Market, and the Regal Continental Stadium 10 Movie Theater and Laser Quest, a laser tag facility. The south end of the neighborhood holds Marina Square Shopping Center, a large mall area with sandwich delis, a wine shop, a coffeehouse and apparel outlets. Hampden South has an eclectic selection of restaurants throughout the area, including several seafood eateries.. Other neighborhood amenities include a U.S. Post Office, a Walmart Supercenter and a  Dairy Queen. Hampden South also holds several outdoor recreational spaces including Wallace Park, Rosamond Park, Eastmoor Park and Southmoor Park.

Hampden South directly abuts Denver Tech Center, a business district known as being home to many major tech companies.