Tierwester Oaks is a residential neighborhood in the southern region of Houston, approximately 4 miles south of the downtown hub. The area borders the campus of Texas Southern University and is near to the University of Houston. Tierwester Oaks span between Tierwester Street and Scott Street. Major motorways in the area include Interstate 45 and Interstate 610. Public bus transportation around the city of Houston is readily available.

The neighborhood is surrounded by some of Houston's finest amenities and attractions. Approximately a mile west of Tierwester Oaks lies Hermann Park, a large green space that holds the Houston Zoo, Miller Outdoor Theater, Hermann Park Golf Course and the Houston Museum of Natural Science. To the east of the neighborhood rests Mac Gregor Park and Gus Wortham Golf Course. Less than half a mile south of Tierwester Oaks there is the Brays Bayou Trail, a 17.9 mile running and biking path that goes along a large waterway.

A block north of the neighborhood along Scott Street there is a grocery store as well as several fast food chain restaurants. This stretch of road also holds a bookstore and a library.